Special Protein in Zebrafish May Lead to Full Spinal Cord Repair

Nov 04, 2016 – By Rhenn Anthony Taguiam


Researchers have discovered that zebrafish — the two-buck wonders in pet stores — may actually hold the key to do full spinal cord repair. It seems the zebrafish is capable of healing a completely severed spinal cord with special proteins.

An injury of this kind in humans can be paralyzing and can even lead to fatal conditions.

Researchers from Duke University have discovered that zebrafish possess a special protein that allows them to heal their severed spine. According to Medical Xpress, the study, published in Science, could lead to developments in tissue repair in humans.

Duke University’s Kenneth Poss claimed this is one of “nature’s most remarkable feats of regeneration.” This is because its potential implications and usage in the world of medicine is astounding. There are currently very limited methods of tissue repair, and animals like zebrafish may hold the key.

A zebrafish’s severed spinal cord forms a literal “bridge” that connects the gap in the injury. Cells form and extend to distances 10 times their own length to heal themselves. By eight weeks, the animals may have already fully reversed their paralysis.

Poss and his team conducted “molecular fishing” to find out which genes are responsible for such activity. It appears the CTGF or the connective tissue growth factor increases while the supporting cells appear to repair the injury.





Josh Sandberg

Josh Sandberg is the President and CEO of Ortho Spine Partners and sits on several company and industry related Boards. He also is the Creator and Editor of OrthoSpineNews.

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