Integra LifeSciences Announces First Surgery With Paramount(R) Pedicle Screw System for Minimally Invasive Spine Surgery

PLAINSBORO, N.J., Jan. 11, 2010 (GLOBE NEWSWIRE) — Integra LifeSciences (Nasdaq:IART) announced today that the first surgery using Integra Spine’s Paramount(R) Pedicle Screw System for minimally invasive spine surgery was performed by Dr. Andrew Parkinson, of Orthopedic Associates of Oklahoma City, Oklahoma.

“The surgery went smoothly. My patient had degenerative disc disease in the L5-S1 disc space and I used the Paramount(R) Pedicle Screw System for minimally invasive spine surgery to provide secondary posterior fixation, after first placing my anterior PEEK device,” said Dr. Parkinson. “The Paramount(R) system offers my patients a safe, effective minimally invasive procedure, with potentially less blood loss and less muscle trauma to the posterior musculature.”

A unique feature of the Paramount(R) Pedicle Screw System is the rod delivery method, wherein the rod is already attached to the polyaxial head, helping to streamline the fusion procedure and reduce the number of operative steps for the surgeon. The system also features a novel compression/distraction system and a robust rod reduction system. Additionally, the advanced Paramount(R) screw delivery system uses a proprietary non-cannulated screw design with a K-wire guided tip for accurate screw placement and enhanced screw strength. “Bringing the Paramount(R) system back to market gives the surgical community a unique and innovative solution for screw and rod delivery,” said Dr. Parkinson.

An estimated 450,000 thoraco-lumbar fusions were performed in the U.S. in 2009 to treat spinal disorders. Spine surgeons typically perform these procedures using highly invasive open techniques. The Paramount(R) system gives surgeons a minimally invasive option to place the pedicle screws through a percutaneous tube. Patient benefits may include faster procedures, reduced blood loss, less tissue trauma, reduced postoperative pain and a shorter hospital stay.

The Paramount(R) system is distributed through the Integra Spine independent distributor network. Integra Spine is a leading provider of fusion implants and orthobiologics used in spinal surgery. Visitwww.integraspine.com for more information.

Integra LifeSciences Holdings Corporation, a world leader in regenerative medicine, is a global medical device company dedicated to improving the quality of life for millions of patients every year. The company’s products are used primarily in orthopedics, neurosurgery and general surgery. Headquartered in Plainsboro, New Jersey, Integra has research and manufacturing facilities throughout the world. For more information visitwww.integra-ls.com.

This news release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements concerning the future use of the Paramount(R) system. Such forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from predicted or expected results. Among other things, the willingness of physicians to use this product may affect the prospects for their use in clinical procedures. In addition, the economic, competitive, governmental, technological and other factors identified under the heading “Risk Factors” included in Item IA of Integra’s Annual Report on Form 10-K for the year ended December 31, 2008 and information contained in subsequent filings with the Securities and Exchange Commission could affect actual results.

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CONTACT:  Integra LifeSciences Holdings Corporation
          Gianna Sabella, Director of Corporate Communications
          (609) 936-2389
          gsabella@integra-LS.com