RTI Surgical® Continues to Advance Science Behind Allograft Implantation

ALACHUA, Fla.–(BUSINESS WIRE)–RTI Surgical, Inc. (RTI) (Nasdaq: RTIX), a leading global surgical implant company, announced that a peer-reviewed, pre-clinical study titled Multipotent adult progenitor cells on an allograft scaffold facilitate the bone repair processhas been published in the latest edition of the Journal of Tissue Engineering.

The pre-clinical study, conducted by Amanda LoGuidice, PhD., used similar materials to the proprietary, patented MAPC^®-based technology used in RTI Surgical’s map3^® Cellular Allogeneic Bone Grafts. The study is the first peer-reviewed, published pre-clinical study comparing multipotent adult progenitor cells (MAPCs) to mesenchymal stem cells (MSCs) in bone healing.

Results demonstrated MAPCs exhibited a more robust angiogenic protein release profile compared to MSCs in vitro. In addition, MAPCs demonstrated enhanced revascularization and new bone formation in vivo in an orthotopic defect model when compared to MSCs when placed on a DBM scaffold.

“We value research that helps us continue to provide surgeons with safe, high-quality implants,” said Carrie A. Hartill, executive vice president and chief scientific officer of RTI Surgical. “We are proud of our advancements in the allograft industry and this study’s results that support the science behind our map3 implant.”

The full study can be viewed here.

About RTI Surgical Inc.

RTI Surgical is a leading global surgical implant company providing surgeons with safe biologic, metal and synthetic implants. Committed to delivering a higher standard, RTI’s implants are used in sports medicine, general surgery, spine, orthopedic, trauma and cardiothoracic procedures and are distributed in nearly 50 countries. RTI is headquartered in Alachua, Fla., and has four manufacturing facilities throughout the U.S. and Europe. RTI is accredited in the U.S. by the American Association of Tissue Banks and is a member of AdvaMed. For more information, please visit www.rtix.com.

MAPC^® is a registered trademark of Athersys, Inc.

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