Biological reconstruction with alcohol-inactivated replantation may help avoid complications

Xu SF, et al. BMC Musculoskelet Disord. 2014;doi:10.1186/1471-2474-15-453.

In a recently published study, researchers found prosthesis-related complications following resection of osteosarcoma in the distal femur could be avoided through biological reconstruction with alcohol-inactivated replantation while still achieving comparable results.

Researchers retrospectively reviewed data for 81 patients who underwent limb-salvage surgery of osteosarcoma in the distal femur. Osteosarcoma was classified into three types, and affected limb reconstruction methods were organized after wide resection. The researchers used Musculoskeletal Tumor Society and quality-of-life scores to analyze patients’ functional and psychological outcomes.

Results showed no differences in functional results or quality-of-life scores among the three reconstruction groups or the three types groups after a mean follow-up of 43 months. Additionally, the researchers observed no differences in tumor-free survival or total survival among three reconstruction groups or three type groups.

The prosthesis group was observed to have better functional scores at 2 years or less compared with the two inactivated-bone groups, according to study findings. – by Casey Tingle

Disclosures: The researchers report no relevant financial disclosures


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Josh Sandberg

Josh Sandberg is the President and CEO of Ortho Spine Partners and sits on several company and industry related Boards. He also is the Creator and Editor of OrthoSpineNews.

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